Aim – To generate a biological and epidemiological
resource for endometriosis research and collaboration.
Biomarker and drug target discovery, and the translation of genetic results into clinically useful outcomes, requires the collection of biological samples along with detailed symptomatic, clinical, and personal information from women with and without endometriosis. For this purpose we started ENDOX, a prospective study in which we systematically collect blood, urine, saliva, and tissue from women undergoing a laparoscopy for pelvic pain, infertility or sterilisation, and asking each participant to complete detailed questionnaires prior to and following surgery. The samples and data collected as part of ENDOX are used for a number of studies aimed at finding – and translating our genetic findings into – biomarkers, improve our understanding of underlying disease mechanisms and develop novel treatments for endometriosis and its associated symptoms. Read more…..
Aim – To identify pre-operative factors predicting
response to surgical treatment of endometriosis associated pain.
Conditions associated with chronic pain (e.g. fibromyalgia and irritable bowel syndrome) are known to be associated with an upregulation of the central nervous system (central sensitization), which may partly be responsible for a continuing sensation of pain when no persistent peripheral cause can be identified. Chronic pain is also known to be associated with psychological distress and a suppression of the body’s natural response to stress (corticosteroids). We are investigating women with moderate severe endometriosisassociated pain both prior to surgery and until 6 months post surgery, aiming to identify factors predicting a good response to surgery. The data we will collect include clinical information, hormonal measures (including cortisol), psychological assessments and a MRI brain scan to measure their central response to pain. Read more…
Aim – To test the potential benefit of long acting progestogens in addition to laparoscopic surgery for endometriosis.
Endometriosis is often a chronic disease with relatively high recurrence rates regardless of the therapeutic approach. Laparoscopic surgery is one of such options. The PRE-EMPT (Preventing Recurrence of Endometriosis by means of Long Acting Protestogen Therapy) trial is a multi-centre, randomised controlled trial (RCT) that aims to evaluate the clinical and cost-effectiveness of the long acting progestogens such as DMPA and LNG IUS system in the prevention of the recurrence of endometriosis. Read more…